P024 Repeated cycles of DSS inducing a chronically relapsing inflammation: A novel model to study fibrosis using in vivo MRI T2 relaxometry
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چکیده
منابع مشابه
Unique Gene Expression and MR T2 Relaxometry Patterns Define Chronic Murine Dextran Sodium Sulphate Colitis as a Model for Connective Tissue Changes in Human Crohn’s Disease
INTRODUCTION Chronically relapsing inflammation, tissue remodeling and fibrosis are hallmarks of inflammatory bowel diseases. The aim of this study was to investigate changes in connective tissue in a chronic murine model resulting from repeated cycles of dextran sodium sulphate (DSS) ingestion, to mimic the relapsing nature of the human disease. MATERIALS AND METHODS C57BL/6 mice were expose...
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ژورنال
عنوان ژورنال: Journal of Crohn's and Colitis
سال: 2012
ISSN: 1873-9946
DOI: 10.1016/s1873-9946(12)60045-2